不孕症患者性激素及抗体水平的研究

摘要

Objective To explore the levels of endocrine hormone and immune antibody in patients with infertility . Methods Immunoluminometric assay was used to detect the serum levels of luteinizing hormone (LH),follicle-stimulating hormone(FSH),estradiol(E2),progesterone(P),prolactin(PRL),testosterone(T) in 130 cases of infertility and 70 healthy controls,and enzyme-linked immunosorbent assay was used to detect the levels of endometrial antibody IgG ,IgM and antisperm antibody IgG ,IgM.Results The positive rate of endometrial antibody and antisperm antibody was 32.3%(42/130) in infertility group,which was higher than that(8.6%,6/70) in the control group(P<0.05).The levels of E2,P in the infertility group were significantly lower than those in the control group (P<0.05),the levels of FSH, LH,PRL,T in the infertility group were significantly higher than those in the control group (P<0.05).The levels of LH,FSH,PRL,T increased significantly while the levels of E 2,P decreased significantly in the immune antibody IgM-positive group(P<0.05).Conclusion Infertility correlates with endometrial antibody ,antisperm antibody and endocrine hormone disorder .%目的：探讨不孕症患者性激素水平及免疫抗体水平。方法用免疫发光法检测130例不孕症患者及70例健康对照组血清促黄体生成素（ LH）、促卵泡生成素（ FSH）、雌二醇（ E2）、孕酮（ P）、泌乳素（ PRL）、睾酮（ T）水平；用酶联免疫吸附法测定抗子宫内膜抗体IgG、IgM和抗精子抗体IgG、IgM水平。结果不孕症组患者抗子宫内膜抗体、抗精子抗体阳性率为32．3％（42/130），明显高于对照组的8．6％（6/70）（P＜0．05）；不孕症组E2、P水平低于对照组（P＜0．05），FSH、LH、PRL、T水平高于对照组（P＜0．05）；免疫抗体IgM阳性组的LH、FSH、PRL、T水平明显增高，E2、P水平明显降低（P＜0．05）。结论不孕症与抗子宫内膜抗体和抗精子抗体及性激素分泌紊乱有一定关联。