VEGF-1154 G／A基因多态性与EB 病毒在鼻咽癌发生中的交互作用研究

摘要

目的：探讨广西人群中鼻咽癌的发病与VEGF-1154 G/A基因多态性、EB病毒的交互作用。方法选择鼻咽癌的患者197例为病例组，另选择在体检中心进行体检的健康人群197例为对照组，采用病例-对照研究方法分析鼻咽癌发病与VEGF-1154 G/A基因多态性、EB病毒的交互作用。结果 VEGF-1154基因型GG、GA＋AA在病例组中的频率分别为40．0％、60．0％，在对照组中的频率为55．8％、44．2％，差异有统计学意义（P＜0．05）。等位基因A在病例组中的分布（40．4％）明显高于对照组（26．9％）（P＜0．05），与等位基因G相比，携带有等位基因A的基因型可增加鼻咽癌的发病风险（ P＜0．05）。但VEGF-1154等位基因A与EB-VCA-IgA、肿瘤家族史在鼻咽癌的发病过程中无交互作用（ P＞0．05）。结论 VEGF-1154等位基因A是鼻咽癌发生的风险因素，但其与EB病毒感染、肿瘤家族史在鼻咽癌的发生过程中无交互作用。%Objective To explore the association of development of nasopharyngeal carcinoma in Guangxi population with VEGF-1154G/A gene polymorphism and EB virus .Methods One hundred and ninety-seven patients with nasopharyngeal carcinoma were in the case group ,197 healthy people in the control group .A case-control study was applied to analyzing the association of development of nasopharyngeal carcinoma with VEGF -1154G/A gene polymorphisms and EB virus . Results The distributions of VEGF-1154 GG(40.0%) and GA+AA(60.0%) in the case group differed from those (55.8%,44.2%) in healthy controls(P<0.05).Compared with the control (26.9%),the frequency of A allele in the case group(40.4%) was significantly higher (P<0.05).The genotype G/A or A/A containing A allele in contrast to genotype G/G increased the risk of nasopharyngeal carcinoma (P<0.05).However,there were no interactions among VEGF-1154 A allele ,EB-VCA-IgA and family history of cancer in the process of occurrence of nasopharyngeal carcinoma (P>0.05).Conclusion VEGF-1154 A allele is a risk factor of nasopharyngeal carcinoma ,but there are no interactions among VEGF-1154 A allele,EB-VCA-IgA and family history of cancer in the process of occurrence of nasopharyngeal carcinoma .