白内障超声乳化吸出术中虹膜松弛综合征的危险因素

摘要

目的：探讨白内障超声乳化吸出术中虹膜松弛综合征（ IFIS）的发生及其危险因素。方法行白内障超声乳化吸出加人工晶体植入术患者654例，对可能影响IFIS发生的因素，如术前用药及其服用时间、并发疾病等，采用logistics单因素及二分类回归分析IFIS发生的高危因素。结果654例708眼术中发生IFIS 19眼（19例），发生率为2．68％。19例术中发生IFIS患者中，服用坦洛新11例（57．89％），合并糖尿病患者10例（52．63％），合并高血压7例（36．84％），有2例IFIS患者术前并未服用任何药物或有其他基础疾病。多因素logistics非条件回归分析结果显示，服用坦洛新及合并糖尿病为IFIS的危险因素（P＜0．05）。不同坦洛新服用时间的患者IFIS的发生率比较，差异无统计学意义（P＞0．05）。结论白内障超声乳化吸出术中IFIS的发生与服用坦洛新及合并糖尿病有关，但与服用坦洛新时间的长短无关。%Objective To explore the incidence and risk factors of intraoperative floppy iris syndrome (IFIS) during phacoemulsification. Methods A total of 654 patients undergoing phacoemulsification and intraocular lens implantation were enrolled .The potential factors influencing the incidence of IFIS ,such as the preoperative medication ,the duration of taking drugs ,complications and etc .,were recorded . Univariate logistic analysis and binary logistic analysis were used to analyze the risk factors for IFIS .Results Among 708 eyes ( 654 cases),IFIS occurred in 19 eyes(19 cases),and the incidence of IFIS was 2.68%.Of the 19 cases,11 were taken tamsulosin(57.89%), 10 were complicated with diabetes (52.63%),7 were complicated with hypertension(36.84%),2 without preoperative medication or other basic diseases .Multivariate logistic unconditional regression analysis revealed that the use of tamsulosin and being complicated with diabetes were the risk factors for IFIS(P<0.05).There was no significant different in the incidence of IFIS among the patients with different taking durations of tamsulosin(P>0.05).Conclusion IFIS occurs during phacoemulsification correlates with the used of tamsulosin and being complicated with diabetes ,but does not correlate with the taking duration of tamsulosin .