糖尿病并发冠心病患者的红细胞比容水平及其意义

摘要

目的 探讨糖尿病并发冠心病患者的红细胞比容(Hct)水平及其意义.方法 回顾性分析917例糖尿病患者的临床资料,其中单纯糖尿病患者(糖尿病组)392例、并发冠心病患者(糖尿病+冠心病)组525例,比较两组的Hct水平及其他实验室检查指标.(糖尿病+冠心病)组患者根据冠状动脉病变累及支数分为单支病变亚组261例、双支病变亚组111例和三支病变亚组153例,根据Gensini积分分为低分组262例和高分组263例,比较各组间的Hct水平.分析糖尿病并发冠心病患者Hct水平与Gensini积分、超敏C反应蛋白(hs-CRP)水平和心功能的相关性.结果 (糖尿病+冠心病)组LDL、hs-CRP和Hct水平高于糖尿病组(均P<0.05).单支病变亚组、双支病变亚组、三支病变亚组Hct水平依次升高(均P<0.05),高分组Hct水平高于低分组(P<0.05).糖尿病并发冠心病患者Hct水平与Gensini积分和hs-CRP水平呈正相关(P<0.05),而与左室射血分数呈负相关(P<0.05).结论 糖尿病并发冠心病患者的Hct水平升高,监测Hct有助于评估糖尿病患者冠状动脉病变程度和心功能.%Objective To explore the level and significance of hematocrit ( Hct ) in diabetic patients complicated with coronary heart disease(CHD).Methods Clinical data of 917 diabetic patients were retrospectively analyzed .The patients consisted of 392 patients with diabetes alone ( diabetes group ) and 525 diabetic patients complicated with CHD ( diabetes+CHD group ) ,and the Hct level and other laboratory indices were compared between the two group .The diabete +CHD group was divided into single-vessel disease subgroup (n=261),double-vessel disease subgroup(n=111) and three-vessel disease subgroup(n=153) according to the amount of coronary artery lesions,and was divided into low score group(n=262) and high score group(n=263) according to the Gensini score,then the Hct level was compared among subgroups .The correlation of Hct level with Gensini score ,high-sensitivity C-reactive protein ( hs-CRP) level and cardiac function was analyzed in the diabetic patients complicated with CHD .Results The levels of LDL,hs-CRP and Hct in the diabetes+CHD group were higher than those in the diabetes group (all P<0.05).Hct level increased in the order of the single vessel disease subgroup,the double-vessel disease subgroup and the three-vessel disease subgroup (all P<0.05).Hct level in the high score group was higher than that in the low score group (P<0.05).In the diabetic patients complicated with CHD ,Hct level positively correlated with Gensini score and hs-CRP level(P<0.05),but negatively correlated with left ventricular ejection fraction (P<0.05).Conclusion Elevated Hct level is observed in the diabetic patients complicated with CHD , and monitoring Hct might contribute to evaluating the coronary artery disease degree and cardiac function of diabetic patients .