新疆维吾尔族宫颈癌患者凝血功能变化及其临床意义

摘要

目的 探讨新疆维吾尔族宫颈癌患者凝血指标的变化及其临床意义.方法 选取111例宫颈癌患者、58例慢性宫颈炎患者及56例健康体检者,均为新疆维吾尔族,其中宫颈癌Ⅰ~Ⅱ期患者48例,宫颈癌Ⅲ~Ⅳ期患者63例,比较宫颈癌、慢性宫颈炎患者和健康体检者间以及不同分期宫颈癌患者间部分凝血酶原时间、凝血酶时间、血浆凝血酶原时间、纤维蛋白原(FIB)、D-二聚体(D-D)水平.结果 维吾尔族宫颈癌患者的FIB及D-D水平高于健康体检者及慢性宫颈炎患者(P<0. 05),宫颈癌Ⅲ~Ⅳ期患者FIB及D-D水平高于宫颈癌Ⅰ~Ⅱ期患者(P<0. 05).结论 宫颈癌患者的FIB和D-D水平升高,提示患者的出血及血栓形成发生风险增高,其在一定程度上能反映患者的疾病进展.%Objective To explore the changes of coagulation indices and its clinical significance in Uygur patients with cervical cancer in Xinjiang. Methods Totally 111 Xinjiang Uygur patients with cervical cancer,including 48 with stageⅠ-Ⅱ and 63 with stageⅢ-Ⅳ,58 Xinjiang Uygur patients with chronic cervicitis,and 56 Xinjiang Uygur healthy subjects were enrolled. The levels of partial prothrombin time( APTT), thrombin time ( TT), plasma prothrombin time ( PT), fibrinogen ( FIB) and D-dimer ( D-D) were compared among patients with cervical cancer,patients with chronic cervicitis and healthy subjects,or among patients with cervical cancer of different TNM stages. Results The levels of FIB and D-D in Uygur patients with cervical cancer were higher than those in healthy subjects and patients with chronic cervicitis(P<0. 05). And the levels of FIB and D-D in patients with stage Ⅲ-Ⅳcervical cancer were higher than those in patients with stageⅠ-Ⅱ cervical cancer(P<0. 05). Conclusion Elevated levels of FIB and D-D are seen in patients with cervical cancer,which might lead to the increasing risk of hemorrhage and thrombosis in the patients,reflecting the disease progression to a certain extent.