盘状结构域受体1蛋白在卵巢癌组织中的表达及其临床意义

摘要

Objective To investigate the expression and clinical significance of discoidin domain receptor 1(DDR1) protein in human ovarian tissues.Methods The expressions of DDR1 protein were detected by immunohistochemical method in 33 normal ovarian tissues,43 benign ovarian tumor tissues and 94 ovarian cancer tissues.The positive expression rates of DDR1 protein were compared among ovarian cancer patients with different clinicopathological features.The relation of the positive expression of DDR1 protein with the prognosis of ovarian cancer patients was analyzed.Results The positive expression rate of DDR1 protein in ovarian cancer tissues was higher than those in the other tissues(all P<0.05),but there was no significant difference between benign ovarian tumor tissues and normal ovarian tissues(P>0.05).The positive expression rates of DDR1 protein were higher in the patients with International Federation of Gynecology and Obstetrics(FIGO) stage Ⅲ-Ⅳ,poor differentiation and peritoneal metastasis than the rates in the patients with FIGO stageⅠ-Ⅱ, moderate/well differentiation and without peritoneal metastasis respectively(all P <0.05).The positive expression of DDR1 protein and peritoneal metastasis were the risk factors for death in the ovarian cancer patients(all P<0.05).Conclusion DDR1 protein is overexpressed in ovarian cancer tissues,probably participates in the occurrence,progression and distal metastasis of ovarian cancer,and may be taken as an important factor for evaluating the prognosis of ovarian cancer patients.%目的 探讨人卵巢癌组织中盘状结构域受体1(DDR1)蛋白的表达情况及其临床意义.方法 运用免疫组化法检测33例正常卵巢组织、43例卵巢良性肿瘤组织及94例卵巢癌组织中的DDR1蛋白表达情况,比较不同临床病理特征卵巢癌患者的DDR1蛋白阳性表达率,分析DDR1蛋白阳性表达与卵巢癌患者的预后关系.结果 卵巢癌组织的DDR1蛋白阳性表达率均高于其他组织(均P<0.05),而正常卵巢组织与良性卵巢肿瘤组织间,差异无统计学意义(P>0.05).国际妇产科联盟(FIGO)分期Ⅲ~Ⅳ期者、低分化者、有腹腔转移者的DDR1蛋白表达阳性率分别高于Ⅰ~Ⅱ期者、中-高分化者高、无腹腔转移者(均P<0.05).DDR1蛋白的阳性表达及腹腔转移是卵巢癌患者死亡的危险因素(均P<0.05).结论 DDR1蛋白在卵巢癌组织中呈高表达,其可能参与卵巢癌的发生发展与远处转移,或可成为评估卵巢癌患者预后的重要因素.