目的：研究转酮醇酶样蛋白1(transketolase-like protein 1,TKTL1)在舌鳞状细胞癌中的表达,并探讨其与临床病理学参数和预后的关系。方法采用免疫组织化学方法检测45例舌鳞状细胞癌组织和对应的舌正常上皮组织中TKTL1的表达,采用log-rank检验分析TKTL1表达与患者预后之间的关系。结果舌鳞状细胞癌组织中TKTL1的阳性表达率(68.89%)高于舌正常上皮组织(15.56%),差异有统计学意义(χ2=26.235,P <0.01)。 TKTL1的高表达与舌鳞状细胞癌患者的年龄、性别和组织分化程度无关(P>0.05),但与舌鳞状细胞癌患者的TNM分期和淋巴结转移密切相关(P<0.05)。通过log-rank检验发现TKTL1高表达的舌鳞状细胞癌患者的存活时间显著低于TKTL1低表达的患者,差异有统计学意义(P<0.05)。结论 TKTL1的高表达可能与舌鳞状细胞癌的发生、发展及预后关系密切。%Objective To investigate the expression of TKTL1 ( transketolase-like protein 1 ) gene and its correlation with clinicopathological characteristics and prognosis of human tongue squamous cell carcinoma. Methods Immunohis-tochemistry was used to detect the TKTL1 protein levels in 45 human tongue cancer specimens and matched normal tis-sues. Results The positive expression ratio of TKTL1 protein in tongue squamous carcinoma tissues ( 68. 89%) was sig-nificantly higher than that in normal tissues ( 15. 56%) , and the difference was statistically significant (χ2 =26. 235, P<0. 01) . The high level of TKTL1 was not statistically correlated with age, gender and tumor differentiated degree ( P>0. 05) , however it was associated with TNM staging and lymph node metastasis ( P<0. 05) notably. Mantel-Cox demon-strated the survival time of patients with high TKTL1 expression was significantly lower than those with low TKTL1 expres-sions. Conclusion It suggests a high TKTL1 expression may be tightly related to the occurrence, development, progres-sion and prognosis of human tongue squamous cell carcinoma.
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