1,10-菲咯啉及其衍生物铜配合物的合成、表征及其抗肿瘤作用

摘要

设计合成了多吡啶铜配合物并通过质谱和元素分析进行了结构表征,对两种配合物体外抑制MCF-7乳腺癌细胞的作用与机理进行初步探讨。结果表明多吡啶铜配合物2具有一定的抗肿瘤活性,能够诱导乳腺癌细胞凋亡,作用机制与下调Bcl-2和上调Bax有关,其抗肿瘤活性与铜配合物的分子结构相关。%To synthesize and characterize two copper(II) complexes by ES-MS,elemental analysis and investigate the anti-tumor activity and mechanism of both complexes.The results suggested complex 2 exhibits promising anti-tumor activity against varied tumor cells.Down-regulation of the Bcl-2 protein and up-regulation of Bax protein may be involved in Cu-induced apoptosis of MCF-7 cells,which involves the binding properties of copper(II) complexes.