舌下络脉与肝癌患者甲胎蛋白、甲胎蛋白异质体3、高尔基体蛋白73的相关性研究

摘要

Objective To know the value of alpha-fetoprotein ( AFP ), alpha fetoprotein heterogeneity3( AFP-L3 ), the Golgi protein ( GP73 ) and sublingual venae score in the diagnosis of HCC , and to discuss the application of the combination of Chinese and Western medicine method in the warning and early diagnosis of HCC. Methods 34 patients with chronic hepatitis B, 65 with liver cirrhosis after hepatitis B, 71 with primary liver cancer and 6 healthy subjects as the control group, test the serum AFP, AFP-L3, GP73 and sublingual venation score, then explore the relationship between the four index using the logistic regression analysis. Results The score of sublingual venae in patients with primary liver cancer ( Hepatocellular Carcinoma, HCC ) is higher than that in the non HCC groups ( I. E. , chronic hepatitis, liver cirrhosis group ); the sublingual venae score is a different index to AFP, AFP-L3, GP73 in the diagnosis of HCC; AFP combined with GP73, and the sublingual venae score in the diagnosis is better than the other three independent, or the two-two joint detection. Conclusion ( 1 )sublingual venae is an independent risk factor for the HCC diagnosis. ( 2 )AFP combined with GP73 and sublingual venae is a simple, cheap, and effective detective method, which is more applicable to the high-risk population in the rural area to realize the early diagnosis of HCC.%目的 了解甲胎蛋白(AFP)、甲胎蛋白异质体3(AFP-L3)、高尔基体蛋白(GP73)及舌下络脉评分在原发性肝癌(hepatocellular carcinoma,HCC)诊断中的价值,探讨中西医结合方法在HCC预警与早期诊断中的应用.方法 慢性乙型肝炎34例、乙肝后肝硬化65例、原发性肝癌71例及健康对照者6例,分别进行血清AFP、AFP-L3及GP73检测及舌下脉络评分,采用logistic回归分析探讨四者间的相互关系.结果 原发性肝癌患者舌下络脉评分高于非HCC各组(即慢性肝炎组、肝硬化组);舌下络脉有别于AFP、AFP-L3、GP73的诊断HCC的指标;AFP联合GP73、舌下络脉联合诊断的意义优于三者独立检测、两两联合检测.结论 (1)舌下络脉是HCC诊断的独立危险因素.(2)AFP联合GP73、舌下络脉检测简便、廉价、有效,适用于基层进行高危人群的筛查,实现HCC的早期诊断.