Objective To compare the changes of quality of life of patients with chemotherapy score at different time points, and explore the preventive effect of ginger partitioned moxibustion on the side effects of chemotherapy and the effect on the quality of life of patients with tumor. Methods Fifty-four ca-ses of cancer patients were randomly divided into treatment and control groups (n=27). Finally, each-group had 25 cases. For the treatment group, “Happyall” moxibustion apparatus with direct contact with fresh ginger partitioned between the skin and the apparatus is applied. Control group uses“happyall” moxi-bustion, with a layer of cardboard between the apparatus and ginger to prevent heat from passing through. Both groups are applied with moxibustion therapy 5 days prior to the start of chemotherapy. Moxibustion is performed on Zusanli (ST36), Guanyuan (CV4), Pishu(BL20) simultaneously, 3 times a week, 20 mi-nutes each session, and this therapy continues until the 60th day in the course of chemotherapy. Tests are performed five days before chemotherapy, on the 21st day, 30th day and the 60th days after chemotherapy. Tests including Karnofsky Performance Scale ( KPS) , QLQ-C30 questionnaires designed by the European Organization for Research and Treatment of Cancer ( EORTC ) to assess the quality of life of cancer pa-tients. Results Comparing the KPS and Quality of Life ( QoL) results between day 21 and day 30 after chemotherapy, both groups exhibit significant decrease in scores ( P <0. 05 ) . Thus, comparing the two groups at the 60th day, the treatment group shows significant increase in both KPS and QoL scores ( P<0. 05) while the control group shows no sign of increase. Conclusion Ginger-partitioned moxibustion be-fore the course of chemotherapy can effectively decrease toxic and side effects induced by chemotherapy, especially pain, nausea and vomiting. This suggests the use of ginger-partitioned moxibustion before and during the course of chemotherapy can prevent the toxic side effects of chemotherapy, and increase the quality of life of cancer patients.%目的：对比不同时间点化疗患者的生存质量评分的变化,探讨隔姜灸疗法对化疗毒副作用的防治作用以及对肿瘤患者生存质量的影响。方法按纳入标准收集受试患者54例,按随机数字表法分为隔姜灸组和假灸组。最终共50例,每组25例。隔姜灸组直接将百笑灸置于鲜姜片上施灸,假灸组在鲜姜片与百笑灸之间放置纸垫施灸。两组均从化疗开始前5天进行治疗,艾灸的穴位为关元、足三里(双侧)、脾俞(双侧),每周3次,每次20分钟,治疗持续至化疗开始后的第60天。分别于开始化疗前5天和开始化疗期第21天、第30天、第60天4个时间点记录患者的卡氏(Karnofsky, KPS)评分以及生存质量量表QLQ-C30(V3．0)中总体健康(quality of life, QoL)评分等项目。结果与化疗开始后第21天比较,两组患者KPS评分和QoL评分在第30天仍明显下降,差异有统计学意义(P<0．05),第60天时隔姜灸组KPS评分和QoL评分显著升高,差异有统计学意义(P<0．05),而假灸组KPS评分和QoL评分没有升高的趋势。与假灸组比较,化疗开始后第60天隔姜灸组KPS评分和QoL评分较假灸组升高,差异有统计学意义( P<0．05)。与化疗前比较,假灸组患者的症状在化疗期均明显加重,差异有统计学意义(P<0．05),而隔姜灸组不良反应有不同程度缓解差异有统计学意义(P<0．05)。结论化疗前介入隔姜灸治疗可以有效减轻化疗毒副作用引发的临床症状,尤其是恶心呕吐和疼痛症状。提示化疗前介入隔姜灸疗法可以防治化疗毒副反应,提高化疗期患者生存质量。
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