Objective To study the characteristics of traditional Chinese medicine ( TCM ) syndrome elements of depression in Parkinson's disease (dPD). Methods All PD patients(254 cases) were divided into depression(HAMD≥8, 135 cases)and non-depression(HAMD<8, 119 cases) groups according to the scores of Hamilton depression rating scale( HAMD) . TCM syndrome elements of two groups were diagnosed by the pattern element scale of PD( PD-PES-13) . The differences in the integral and ratio of TCM syndrome factors in the 2 groups were compared, and the risk degree of TCM syndrome factors on the incidence of dPD was calculated by Logistic regression. Results Compared with the non-depression group, the ratio of yin deficiency syndrome, internal heat syndrome and qi stagnation syndrome in the de-pression group were significantly higher than those in the non depression group ( P<0.05) . The score of yin deficiency syndrome, internal heat syndrome, qi stagnation syndrome and medullary reduction were significantly higher than those of non depression group (P<0.05). The risk degree of TCM syndrome ele-ments to dPD shows that the occurrence of dPD was positively correlated with yin deficiency syndrome ( r=0.518, P=0. 043 ) , internal heat syndrome ( r=0. 712, P=0. 007 ) and qi stagnation syndrome (r=0.716, P=0.014), OR value was 1.679, 2.038 and 2.016 respectively. Conclusions The major TCM syndrome elements of dPD are yin deficiency, internal heat, qi stagnation and medullary reduction , and the first three could increase the risk of dPD.%目的 研究帕金森病抑郁(depression in Parkinson's disease,dPD)的中医证候要素特征.方法 将纳入的帕金森病(Parkinson's disease,PD)患者(254例)按照汉密尔顿抑郁量表(HAMD)分数标准分为抑郁组(HAMD≥8分,135例)和非抑郁组(HAMD<8分,119例),采用帕金森病证候要素量表(PD-PES-13)进行证候要素辨别,比较2组中医证候要素积分和比率的差异,并利用Logistic回归法计算出中医证候要素对dPD发病的危险度.结果 抑郁组中阴虚证、内热证、气滞证的比率显著高于非抑郁组(P<0.05),阴虚证、内热证、气滞证及髓减证积分显著高于非抑郁组(P<0.05).中医证候要素对dPD的危险度显示,dPD的发生与阴虚证(r=0.518,P=0.043)、内热证(r=0.712,P=0.007)和气滞证(r=0.716,P=0.014)呈正相关性,OR值分别为1.679、2.038和2.016.结论 dPD患者的中医证候要素以阴虚、内热、气滞和髓减为主,且前三者均会增加dPD发病的危险度.
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