骨关节炎软骨下骨的变化及其分子机制的研究进展

摘要

Osteoarthritis (OA) is one of the most common chronic osteoarthritic diseases,which can involve the whole joint.Subchondral bone is an important part of the joint and has a close relationship to the development of OA.The changes and mechanisms of subchondral bone in OA are complex and remain disputes.In this review,we will discuss the advances of the molecular mechanisms of subchondral bone in OA,which include the pathological changes and the roles of the OPG/RANKL/RANK system,transforming growth factor β (TGFβ),estrogen-estrogen receptors and lipid metabolism in OA.%骨关节炎(osteoarthritis,OA)是一种最常见的慢性骨关节疾病,可累及整个关节.软骨下骨作为关节的重要组成部分,与OA的发生发展密切相关.OA中软骨下骨变化的机制复杂,目前尚未完全阐明.本文通过文献回顾对OA中软骨下骨的病理变化,OPG/RANKL/RANK系统、转化生长因子p(transforming growth factor β,TGFβ)、雌激素-雌激素受体信号通路和脂代谢等因素对软骨下骨的影响进行综述,探讨OA中软骨下骨变化的作用及其分子机制.