酒精依赖者认知功能评估的探索研究

摘要

ABSTRACT:ObjectiveTo assess cognitive function in patients with alcohol dependence syndrome to provide a foundation of clinical diagnosis and treatment for such kind of disease and offer a reference for evaluating whether alcohol-dependent patients are able to take responsibility, either full or partial.Methods27 patients with alcohol dependence syndrome were chosen and received two tests of visual choice reaction time and cancellation efficiency before and after treatment, respectively. 30 healthy volunteers, whose gender, age and education background were matched with the patients, were selected as the control group and received the above same two tests before and after drinking alcohol but with the latter being conducted when no signs of ethanol and acetaldehyde showing in the subject’s blood. Finally the data were processed with the analysis of variance.ResultsCompared with the control group, the patients of alcohol dependence syndrome had statistically significant difference in the two tests either pre- or post- treatment (P0.05).ConclusionsPart of the cognitive function of alcohol-dependent patients is damaged irreversibly no matter whether treatment has been made or not.%目的：评估酒精依赖综合征患者的认知功能状态，为酒精依赖者临床诊疗与评估提供研究基础，为这类患者有无完全或部分责任能力的评判提供参考依据。方法选取27名酒精依赖综合征患者，分别于治疗前后进行视觉选择反应时和划消效率两项测试，同时选取30名性别、年龄、文化程度与酒精依赖综合征患者相匹配的健康志愿者，分别于饮酒前后进行相同测试，所得数据进行方差分析。结果相对于健康人群，酒精依赖患者的视觉反应时和划消效率均存在显著差异(P＜0.01)，并且治疗前后相比差异也具有统计学意义(P＜0.05)，而健康人饮酒前后无统计学意义(P＞0.05)。结论酒精依赖患者部分认知功能受到了不可逆的损害。