蚕蛹油α-亚麻酸对实验性高血脂大鼠的降脂作用

摘要

目的：研究蚕蛹油（silkworm pupa oil,SPO）α-亚麻酸（α-linolenic acid）对实验性高血脂大鼠的预防和治疗作用。方法：建立远交群（sprague dawley,SD）大鼠高脂血症模型,预防性及治疗性给予蚕蛹油α-亚麻酸,测定并分析对大鼠血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A-I（apolipoproteinA-I,Apo A-I）及脂蛋白酯酶（lipoprotein lipase,LPL）和肝脂酶（hepatic lipase,%Objective： To investigate the preventive and therapeutic effects of α-linolenic acid from silkworm pupa oil in hyperlipidemic rats.Methods： Hyperlipidemia in SD rats was induced by feeding high-fat diet.α-Linolenic acid from silkworm pupa oil was also fed to the model rats.The contents of serum triglyceride（TG）,total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C） and apolipoprotein AI（Apo A-I） were determined,and the activities of lipoprotein lipase（LPL） and hepatic lipase（HL） were analyzed.Results： α-Linolenic acid from silkworm pupa oil could result in a significant decrease in the contents of TC and TG,and an increase in the contents of HDL-C and Apo A-I and the activities of LPL and HL in hyperlipidemia rat serum.Conclusion： α-Linolenic acid from silkworm pupa oil has significantly preventive and therapeutic effects in hyperlipidemia rats.