Experimental Studies of Melanin Associated Antigen and Its Relationship with Sympathetic Ophthalmia and Vogt-Kayanagi-Harada Syndrome

摘要

＜正＞ Purpose:To discuss the relationship of Bovine Melanin-Associated Antigen （BMAA） to Sympathetic Ophthalmia （SO） and Vogt-Kayanagi-Harada （VKH） syndrome.Methods:BMAA was isolated and purified from bovine iris and ciliary body and MTT method was used to measure the peripheral lymphocyte reactions of SO and VKH syndrome patients to BMAA. 15 cases of SO were included in the SO group with 11 males and 4 females.The average age was 37.5, ranging from 23 to 56 years; 15 patients with VKH syndrome were included in the VHK group with 7 males and 8 females. Their average age was 37.2 years, ranging from 24 to 69 years; 20 normal individuals without ocular and systemic autoimmune diseases were included in the control group. These included 9 males and 11 females, aging from 14 to 28 with an average of 23.8 years.Results:The OD values of each group were as follows: SO controls 0.327±0.032; SO+BMAA 0.490±0.758; SO+PHA 0.5310±0.918; VKH controls 0.328±0.503; VKH+BMAA 0.430±0.530; VKH+PHA 0.328±0.484; Normal contr