目的：探讨抗菌药物专项监管措施对Ⅰ类切口手术患者围术期抗菌药物预防使用的影响。方法：南京市高淳人民医院（以下简称“我院”）从2012年4月起对临床应用抗菌药物实行专项监管措施，对实施前（2012年1-3月，A组）、后（2013年1-3月， B组）Ⅰ类切口手术患者围术期抗菌药物使用情况进行对比分析。结果：实行专项监管措施后，我院Ⅰ类切口手术患者术前使用抗菌药物比例明显下降（P＜0�05），且以单一用药为主；使用的抗菌药物种类和频次方面，则以第1、2代头孢菌素及青霉素等非限制使用级抗菌药物为主；用药合理性明显提高，住院各项费用下降明显，与实施前比较，差异有统计学意义（ P＜0�05）。结论：对临床应用抗菌药物实行专项监管措施能有效提高医院Ⅰ类切口手术患者围术期预防性应用抗菌药物的合理性水平。%OBJECTIVE:To investigate the effect of the implementation of specific regulatory measures on perioperative use of antibiotics in patients undergoing type Ⅰ incision operation. METHODS: The special regulatory measures were carried out in Nanjing Municipal Gaochun People’ s Hospital(“our hospital”) since Apr. 2013. The perioperative use of antibiotics in patients undergoing type I incision operation before vs. after intervention [ Group A (from Jan. 2012 to Mar. 2012) vs. Group B (from Jan. 2013 to Mar. 2013)] were analyzed. RESULTS:After the implementation of specific regulatory measures, the ratio of patients using antibiotics was significantly decreased as compared with before intervention (P<0�05), and the antibiotics were mostly used singly. In terms of drug types and application frequency, non-restricted level of antibiotics such as first and second generation cephalosporin and penicillin took the lead. The rationality in antibiotic use improved significantly, with hospitalization costs decreased significantly, showing statistically significant differences as compared with before intervention ( P < 0�05 ) . CONCLUSIONS: The implementation of special regulatory measures on clinical use of antibiotics effectively improved the rational level of the perioperative use of prophylactic antibiotics.
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