目的：了解抗菌药物所致药品不良反应（ADR）发生的特点，为临床合理用药提供参考。方法：收集我院2007-2013年收集上报至国家ADR监测网的抗菌药物所致ADR报告225例进行回顾性分析。结果：225例ADR报告中，共涉及7大类27个品种抗菌药物。其中头孢菌素类所致的ADR居首位（44.58％）；静脉滴注（97.50％）给药途径最容易引发ADR；ADR累及器官或系统以皮肤及其附件损害最为常见（56.33％）。结论：应重视抗菌药物的合理使用，加强ADR报告和监测工作，以减少ADR的发生，保障患者用药安全。%OBJECTIVE:To investigate the characteristics of antibiotic-induced adverse drug reactions (ADRs) so as to pro-vide reference for clinical rational use of antibiotics. METHODS:A total of 225 ADR cases submitted by our hospital to National ADR Monitoring network during 2007-2013 period were retrospectively analyzed. RESULTS:7 categories and 27 antibiotics were involved in the 225 ADR cases. The ADR cases induced by cephalosporins dominated the first place(44.58%),induced mostly by drip infusion (97.50%) and manifested mostly as lesions of skin and its appendages (56.33%). CONCLUSIONS:Great impor-tance should be attached to rational use of antibiotics as well as strengthening ADR reporting and monitoring so as to reduce the oc-currence of ADR and ensure patients’medication safety.
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