癫痫患者丙戊酸血清浓度监测及与临床疗效的关联性分析

摘要

目的:研究癫痫患者丙戊酸血清浓度监测结果,为临床合理用药提供参考.方法:采用荧光偏振免疫法检测癫痫患者丙戊酸血清浓度,分析性别、年龄、合并用药对丙戊酸血清浓度的影响及丙戊酸血清浓度与疗效的关系.结果:性别差异可能并不是丙戊酸血清浓度的影响因素.丙戊酸血清浓度与患者年龄呈负相关,0~18岁组丙戊酸血清浓度为(66.12 ±28.08) μg/ml,明显高于19~59岁和60岁以上年龄组的(57.53 ±29.85)、(51.72 ±22.60) μg/ml,差异有统计学意义(P100 μg/ml;丙戊酸血清浓度位于50~100 μg/ml癫痫治疗有效率90.60%(241/266),明显高于100 μg/ml的76.74%(33/43),差异均有统计学有意义(P100μg/ml.The effective rate of epilepsy treatment in range of 50~100μg/ml of serum concentration of VPA was 90.60%(241/266),significantly higher than that in range of 100μg/ml 76.74%(33/43),with statistically significant difference ( P <0.05 ); which showed that there were significant correlation between the serum concentration of VPA and clinic efficacy.CONCLUSIONS:Monitoring of the serum concentration of VPA can provide objective evidence for formulating individualized therapeutic regimen in patients with epilepsy.