三联幽门螺杆菌根除疗法与奥美拉唑、铝碳酸镁联合治疗胃溃疡的疗效观察

摘要

OBJECTIVE:To probe into the efficacy of rabeprazole triple therapy of Helicobacter pylori ( Hp ) eradication combined with omeprazole and hydrotalcite in treatment of gastric ulcer .METHODS: 60 cases admitted into Liaoning Rongjun Hospital from Mar .2014 to Mar.2016 were selected to be divided into observation group and control group via the random number table , with 30 cases in each.Two group of patients were treated with rabeprazole triple therapy of Hp eradication , and based on which the control group additionally received omeprazole , while the observation group were additionally treated with hydrotalcite based on the control group .The treatment effects , Hp eradication rate were compared between two groups .RESULTS:The cure and excellence rate of observation group was 83.3%(25/30), significantly higher than that of control group [60.0%(18/30)], with statistically significant difference ( P <0.05 ) .The Hp eradication rate , incidence of adverse drug reactions in observation group were respectively 93.3%( 28/30 ) and 3.3%( 1/30 ) , significantly higher than those of control group [ 76.7%( 23/30 ) and 16.7%(5/30)], with statistically significant difference (P<0.05).CONCLUSIONS:The efficacy of rabeprazole triple therapy of Hp eradication combined with omeprazole and hydrotalcite in treatment of gastric ulcer is significant , with high cure rate , low incidence of adverse drug reactions and high Hp eradication .%目的：探讨三联幽门螺杆菌（helicobacter pylori，Hp）根除疗法与奥美拉唑、铝碳酸镁联合治疗胃溃疡的疗效。方法：选取2014年3月—2016年3月辽宁省荣军医院收治的Hp感染胃溃疡患者60例作为研究对象，按照随机数字表法分为观察组和对照组，每组各30例。2组患者在治疗的第1周均采用三联Hp根除疗法，对照组患者在三联Hp根除疗法的基础上给予奥美拉唑治疗，观察组患者在对照组的基础上给予铝碳酸镁治疗。比较2组患者的治疗效果、Hp根除率。结果：观察组患者治愈及显效率为83.3％（25／30），显著高于对照组的60.0％（18／30），差异有统计学意义（P＜0.05）；观察组患者Hp根除率、不良反应发生率分别为93.3％（28／30）、3.3％（1／30），均明显优于对照组的76.7％（23／30）、16.7％（5／30），差异均有统计学意义（P＜0.05）。结论：三联Hp根除疗法与奥美拉唑、铝碳酸镁联合治疗胃溃疡，治愈率高，不良反应发生率低，Hp根除率高，具有良好的治疗效果。