Objective To explore the female menopause depression nursing intervention effect. Methods 50 cases offemale climacteric depression were selected in 2013, computers were randomly divided into control group and treatment group as a clinical research object, the control group of 25 cases of female climacteric depression wereonly given antidepressant drugs and general care treatment; 25 cases of female climacteric depression patients in the treatment group in the concurrent administration of antidepressant treatment increase the nursing interventiontherapy. Comparison between the treatment group and the control group of female climacteric depression inpatients with antidepressant treatment and different nursing method, self rating scale before and after treatmentthe scores in SDS depression, and analysis and discussion. Results The patients in the treatment group after drug treatment and nursing intervention, SDS self rating Depression Scale score relatively low, the treatment effect is better than that of control group. (P<0.05), the result of the data with statistical significance. Conclusion The curative effect of nursing intervention on antidepressants female climacteric depression patients, very good,not only make the depression psychological response in patients with ease, but also improve patients mental outlook, with improving effects on the patients with nervous system function, so that patients with endocrine systemfunction tends to be normal or even higher level, compared with the control group use nursing the traditional method, its advantage is obvious, it is worth in clinical application.%目的：探讨女性更年期抑郁症实施护理干预的效果。方法在2013年中选取女性更年期抑郁症患者50例，计算机随机分为对照组和治疗组作为临床研究对象，各25例。对照组中25例女性更年期抑郁症患者给予抗抑郁药物和一般的护理治疗；治疗组的25例女性更年期抑郁症患者则在给予抗抑郁药物治疗的同时增加护理干预疗法。对比治疗组和对照组女性更年期抑郁症患者进行抗抑郁药物治疗和不同的护理方法后，在SDS中治疗前后分值的变化，并分析讨论。结果治疗组患者在经过药物治疗和干预护理后，SDS分值较低，疗效明显优于对照组。差异有统计学意义（P＜0.05）。结论护理干预在服用抗抑郁药物的女性更年期抑郁症患者中，疗效甚佳，不仅使患者的抑郁心理反应得到减轻，还改善了患者的精神面貌，对患者神经系统功能有着提高作用，使患者内分泌系统功能趋于正常甚至较高水平，与使用传统方法护理的对照组相比，其优势明显，值得在临床中推广应用。
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