新型质子泵抑制剂艾普拉唑的综合评价与临床应用进展

摘要

Objective: Analyze the mechanism of Ilaprazole, measure its clinical effects and characteristics. Provide theoretical and evidence-based support for the rational use of clinical.Method: Collect and analyze the domestic and international periodical literatures. Summary of relevant pharmacological and pharmacokinetic studies, Introduction of the domestic and foreign listing of the drug.Results: Ilaprazole can be potent acid suppression, inhibition of the CYP2C19 enzyme was small, good safety and efficacy of acid related diseases is clear, with a better economy. Conclusion: Compared to previous generations of PPI, Ilaprazole has certain advantages in both Pharmacology and Pharmacokinetics where it improves the Clinical efficacy , reduce nocturnal acid breakthrough .thus has possibilities to become an alternative to suppress acids.%目的：介绍艾普拉唑的作用机制、特点，并评价其临床疗效，为临床合理使用提供理论和循证支持。方法：搜集、整理、分析国内外期刊文献，综述相关的药理学、药动学研究结果，介绍该药国内外上市情况。结果：艾普拉唑可强效抑酸，对CYP2C19酶的抑制作用小，安全性好，对酸相关疾病疗效明确，有较好的经济学优势。结论：艾普拉唑相对前几代的质子泵抑制剂在药理学、药动学方面都具有一定的优势，半衰期最长，减少夜间酸突破(NAB)。在临床疗效上也有所提高，可成为临床抑酸治疗新的用药选择。