EFFECT OF CHOLECYSTOKININ-8 MICROINJECTION INTO VENTRAL TEGMENTAL AREA ON DOPAMINE RELEASE IN NUCLEUS ACCUMBENS OF RATS： AN IN VIVO VOLTAMMETRIC STUDY

摘要

Effects of microinjection of cholecystokinin-8 (CCK-8) into the rat ventral tegmental area were studied on dopamine (DA) release from nucleus accumbens (Acb), using fast cyclic vohammetry and carbon fibre microelectrode. DA release was evoked by electrical stimulation of the medial forebrain bundle (MFB). DA release from Acb was increased with increasing intensity or frequency of electrical stimulation in a dose-dependent manner and was inhibited by microinjection of CCK-8 (0.5μg/kg) into the ventral tegmental area.