Objective To observe the alteration of the expression of Cx43in cerebral astrocyte caused by audiogenic seizure.Method Genetic epilepsy prone rat P77PMC was used as a model and immunohistochemical method was applied to detect the time-co urse alteration of Cx43ex-pression in P77PMC rat ’ s cerebral astrocyte.Result After audiogenic seizure,Cx43expression was detected in cerebral cortex and hippocampus and appeared time-dependent increa sing.Conclusion Astrocytes in cerebral cortex and hi ppocampus might be activated by audi ogenic seizure,which might be beneficial to keep the stability of neuron’ s peripheral environment and thus protect the neurons.
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