Expression of intercellular adhesion molecule 1 and interleukin 6 in the rat’s kidney after severe burn and its relation with renal injury

摘要

Objective To clarify the mechanism and provide the basis for prevention and treatme nt of the early injuries of kidney after severe burn in rats.We observed the expression of intercellular adhesion molecule 1and interleukin 6and the early p athological changes in different time.Method Early pathological changes in the kidney were observed by LM and EM.The ex pression of ICAM-1were observed by i mmunohis-tochemistry,in situ hybridization.The expression of IL-6was also obse rved.Result From 5min to 72h after burn,the early changes in the kidney included edema,hemorrhage,and congestion,injury of capillary epithelium cells.2ICAM-1and IL-6w ere higher in the kidney 30min after burn,and from 2h to 24h,they we re strongest positive,but on 72h,th ey were negative.Conclusion ICAM-1and IL-6may play important roles in mechanisms of kid ney injury,and the major target cell s may be the endothelium cells.