These malaria targeting antibodies are band 3 antibodies and they recognize a special configuration of a molecule called band 3 that is present on erythrocytes. The special band 3 configuration is present on the surface of senescent erythrocytes, malaria infected erythrocytes, the erythrocytes of certain hemoglobinnopathies such as sickle cell disease and on the erythrocytes of some metabolic disorders such as G6PD. Note that these hemoglobinopathies and metabolic disorders all aid in the survival of falciparum malaria to such an extent that their incidence is increased in falciparum endemic areas [1-3]. Though there are many adhesive molecules involved in the pathology of falciparum malaria and sickle cell anemia, the focus here is on the band 3 molecules.
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机译:Iniciativa presidencial Contra a malaria:mantendo o momento Contra a malaria。 salvando Vidas非洲。 Quarto Relatorio anual,abril de 2010. sumario Executivo(总统的疟疾倡议:维持抗疟疾的势头。拯救非洲的生命。第四次年度报告,2010年4月。执行摘要)