Effects of glucose-insulin-potassium on baroreflex sensitivity,leftventricular function and ventricular ar-rhythmia in the subacute phase of myocardial infarction in rats

摘要

Objective:Glucose- insulin- potassium (GIK ) is clinically used for reducing mortality in acute myocardial in- farction(MI) .It is known that ventricular arrhythm ia,left ventricular dysfunction and impaired baroreflex sensitivity(BRS) are the three major determinants for predicting the m ortality after acute MI.The present work was designed to study the ef- fects of GIK on BRS,ventricular arrhythm ia,and left ventricular function in rats with coronary artery ligature.Sprague- Dawley rats were used and the myocardial infarction was produced by ligature of the left anterior descending artery.Five weeks after coronary artery ligation,BRS was measured in conscious state with a computerized blood pressure monitoring system and left ventricular function and electrocardiogram were determined in the anaesthetized state in the subacute phase of myocardial infarction.It was found that GIK did not affect the blood pressure and heart period in both conscious and anaes- thetized rats.GIK did not enhance BRS,but reduced ventricular arrhythm ia and improved left ventricular function by reduc- ing left ventricular end diastolic pressure in anaesthetized rats with MI.It is proposed that reducing ventricular arrhythmia and improving left ventricular function contribute to the effect of GIK on reducing the m ortality after