AIM:To examine the antiulcerogenic effects of various extracts of Mentha arvensis Linn on acid,ethanol and pylorus ligated ulcer models in rats and mice.METHODS:Various crude extracts of petroleum ether,chloroform,or aqueous at a dose of 2 g/kg po did not produce any signs or symptoms of toxicity in treated animals.In the pyloric ligation model oral administration of different extracts such as petroleum ether,chloroform and aqueous at 375 mg/kg po,standard drug ranitidine 60 mg/kg po and control group 1 Tween 80,5 mL/kg po to separate groups of Wister rats of either sex(n = 6) was performed.Total acidity,ulcer number,scoring,incidence,area,and ulcer index were assessed.RESULTS:There was a decrease in gastric secretion and ulcer index among the treated groups i.e.petroleum ether(53.4),chloroform(59.2),aqueous(67.0) and in standard drug(68.7) when compared to the negative control.In the 0.6 mol/L HCl induced ulcer model in rats(n = 6) there was a reduction in ulcerative score in animals receiving petroleum ether(50.5),chloroform(57.4),aqueous(67.5) and standard.drug(71.2) when compared to the negative control.In the case of the 90 ethanol-induced ulceration model(n = 6) in mice,there was a decrease in ulcer score in test groups of petroleum ether(53.11),chloroform(62.9),aqueous(65.4) and standard drug ranitidine(69.7) when compared to the negative control.It was found that pre-treatment with various extracts of Mentha arvensis Linn in three rat/mice ulcer models ie ibuprofen plus pyloric ligation,0.6 mol/L HCl and 90 ethanol produced significant action against acid secretion(49.3 ± 0.49 vs 12.0 ± 0.57,P < 0.001).Pre-treatment with various extracts of Mentha arvensis Linn showed highly-significant activity against gastric ulcers(37.1 ± 0.87 vs 12.0 ± 0.57,P < 0.001).CONCLUSION:Various extracts of Mentha arvensis Linn.375 mg/kg body weight clearly shows a protective effect against acid secretion and gastric ulcers in ibuprofen plus pyloric ligation,0.6 mol/L HCl induced and 90 ethanol-induced ulcer models.
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