三种不同方法对未明确诊断意义的不典型鳞状上皮细胞临床应用的分析

摘要

Objective To evaluate the clinical application of three approaches to atypical squamous cells of undetermined significance (ASCUS).Methods 350 ASCUS were divided into 3 groups randomly, the following methods were used to check, including thinprep cytology test(TCT), human papillomavirus(HPV) DNA test, colposcopy and biopsy of cervix.Results In group A, cytologically normal and abnormal(≥ASCUS) cytology detection rate of CIN respectively were 5.41% and 38.63% after repeated TCT. Group B were detected for HPV-DNA, and HPV positive and negative CIN respectively were 54.55%and 3.61%. Group C underwent colposcopy and cervical biopsy, pathological results for the detection rate of CIN 23.27%.Conclusion The use of thinprep cytology test or HPV-DNA test is effective screening method of cervical lesions. Repeated TCT abnormality or HR-HPV infection should be futher colposcopy examination and biopsy of cervix.%目的：评价三种不同检查方法在未明确诊断意义的不典型鳞状上皮细胞（ASCUS）检查中的临床应用价值。方法将350例ASCUS患者随机分为三组，分别进行膜式液基薄层细胞学（TCT）检查、人乳头瘤病毒（HPV）DNA检测、阴道镜检查及宫颈活组织检查。结果A组复查TCT，细胞学正常和异常（≥ASCUS）CIN检出率分别为5.41%和38.63%；B组行HPV DNA检测，HPV阳性和阴性CIN检出率分别为54.55%和3.61%；C组行阴道镜检查及宫颈活组织检查，病理结果为CIN检出率为23.27%。结论应用TCT检查或HPV DNA检测是ASCUS的有效筛查方法，复查TCT异常或高危型HPV感染者，应进一步行阴道镜检查及宫颈活组织检查。