目的：比较健康人和心力衰竭患者的氨基末端B型利钠肽（NT-proBNP）水平，探讨其对心力衰竭的诊断意义。方法对100例临床心力衰竭患者和40例健康人群同时进行超声心动图检查和NT-proBNP检测，比较2组观察指标差异。结果各级心力衰竭组的患者的氨基末端B型利钠肽水平均高于健康人群组。Ⅰ级12例患者（361.4±21.4），Ⅱ级36例患者（652.8±86.1），Ⅲ级41例患者（2741.5±351.2），Ⅳ级11例患者（7381.4±558.1），且随着心力衰竭的严重程度的增高，NT-proBNP水平也明显增高，差异有统计学意义（P<0.05）。在对照组（健康人群），NT-proBNP的检查结果为高龄大于低龄，女性高于男性，糖尿病和高血压组远高于非糖尿病和非高血压组（P<0.05）。在心力衰竭患者组，NT-proBNP的检查结果为高龄大于低龄，糖尿病和高血压组远高于非糖尿病和非高血压组（P<0.05），但是男性与女性比较差异无统计学意义。结论 NT-proBNP水平的检测对诊断心力衰竭有重要意义，但要充分考虑年龄、糖尿病、高血压等因素的影响，以便做出最正确的诊断。%Objective To explore the diagnostic values for heart faliure (HF) by comparing amino-terminal pro-brain natriuretic peptide(NT-proBNP) level of healthy people and patients with HF. Methods 100 HF patients and 40 healthy people were selected as the study objects,examed the objects by ultrasound cardiogram and detected their NT-proBNP,recorded and compared differences between two groups. Results NT-proBNP of all HF patients were significantly higher than healthy people, Grade I in 12 patients Patient(361.4±21.4),Grade Ⅱ in 36 patients Patient(652.8±86.1),Grade Ⅲ in 41 patients Patient(2741.5±351.2),Grade Ⅳ in 116 patients Patient(7381.4±558.1),and the NT-proBNP level increased when HF degree increased, differences were statistically signiifcant(P<0.05).In control group (healthy people), NT-proBNP of elderly people were higher than younger people, of female was higher than male, diabetes and hypertension group was higher than non-diabetes and hypertension group(P<0.05).In HF group, NT-proBNP detection showed that elderly people were higher than younger people, diabetes and hypertension group was higher than non-diabetes and hypertension group, there were no signiifcant differences between male and female. Conclusion NT-proBNP plays an improtant role in the diagnosis of HF, but factors such as age, hypertension, diabetes and so on should be fully considered during diagnosis, so as to make the right conclusion.
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