The protective effect ofMoringa oleifera leaf extract on liver damage in mice infected withPlasmodium bergheiANKA

摘要

Objective:To investigate the protective effect ofMoringa oleifera leaf extract on liver damage in mice infected withPlasmodium bergheiANKA (P. berghei) Methods:For extraction ofMoringa oleifera(M. oleifera)leaves, microwave with hot water method was used and acute toxicity study was then be done. Standard Peters’ test was carried out to test the efficacy ofM. oleifera extractin vivo. TheICR mice were inoculated with 1 × 107 red blood cells infected withP. bergheistrain by intraperitoneal injection. They were subsequently given with 100, 500 and 1 000 mg/kg of this extract by intragastric route once a day for 4 consecutive days. Parasitemia was estimated using microscopy and levels of aspartate aminotransferase, alanine aminotransferase and albumin were also measured. Results: TheM. oleiferaleaf extract showed the protective activity on liver damage in mice infected withP. berghei in a dose-dependent fashion. It can be indicated by normal levels of aspartate aminotransferase, alanine aminotransferase and albumin in mice treated with extract. The 1 000 mg/kg of extract was observed to present the highest activity. Interestingly, the dose- dependent antimalarial activity was also found in the mice treated with extract. Conclusions: TheM. oleiferaleaf extract presented protective effect on liver damage in mice infected withP. berghei.