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《海岸生命医学杂志(英文版)》
>Bioactive potential of some economically important marine gastropods along the Gulf of Mannar region, southeast coast of India
Bioactive potential of some economically important marine gastropods along the Gulf of Mannar region, southeast coast of India
Objective:To analyse the economically important gastropods for prospective antimicrobial, antioxidant and cytotoxic activities from the Gulf of Mannar region, southeast coast of India. Methods: The bioactive potential of some gastropodsi.e. Babylonia spirata (B. spirata), Phalium glaucum, Tonna dolium, Hemifusus pugilinus, Xancus pyrum, Chicoreus ramosus (C. ramosus), Harpa articularis, Ficus ficus andBabylonia zeylanica were analysed. Antimicrobial activity was carried out against 8 human pathogenic bacteria and 3 fungal strains by well diffusion method. Antioxidant and cytotoxic activities were analyzed by standard methods. Results: In antibacterial and antifungal activities, methanolic extract ofB. spirata significantly showed the highest inhibition zone againstAeromonas hydrophila andFusarium spp. (P > 0.05). In the total antioxidant activity, the maximum activity was observed inB. spirata (510μg/mg) and in the 1.1-diphenyl-2-picrylhydrazylscavenging activity,B. spiratashowed the highest percentage of inhibition (76.7%). In the case of cytotoxicityi.e. brine shrimplethality tests the methanolic extract ofC. ramosus showed the lowest percentage of mortality and the LC50 values were found to be 523.9μg/mL. Conclusions: The results revealed that all the gastropods in the present study possessed antimicrobial, antioxidant and cytotoxic effects. However, species likeB. spirata andC. ramosus exhibited potent activity andcan be used for further clinical studies.
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