Hepatoprotective potential of threesargassum species from Karachi coast against carbon tetrachloride and acetaminophen intoxication

摘要

Objective:To assess the hepatoprotective effect of ethanol extracts ofSargassum variegatum (S. variegatum),Sargassum tenerrimum (S. tenerrimum) andSargassum binderi occurring at Karachi coast against carbon tetrachloride (CCl4) and acetaminophen intoxication in rats. Methods:Sargassum species were collected at low tide from Buleji beach at Karachi coast. Effect of ethanol extracts ofSargassum spp., on lipid parameter, serum glucose and kidney function was examined. Liver damage in rats was induced by CCl4 or acetaminophen. Rats were administered with ethanol extracts ofS. tenerrimum,S. variegatum andSargassum binderi at 200 mg/kg body weight daily for 14 days separately. Hepatotoxicity was determined in terms of cardiac and liver enzymes and other biochemical parameters. Results:S. variegatum showed highest activity by reducing the elevated level of hepatic enzymes, bilirubin, serum glucose, triglyceride with restoration of cholesterol. Urea and creatinine concentrations were also significantly (P < 0.05) reduced as compared to acetaminophen intoxicated rats.S. tenerrimum andS. variegatum showed moderate activity against CCl4 hepatic toxicity. Conclusions: The protective role ofS. variegatum against acetaminophen liver damage and its positive impact on disturbed lipid, glucose metabolism, kidney dysfunction andS. tenerrimum against CCl4 liver toxicity suggest thatSargassum species offer a non-chemical means for the treatment of toxicity mediated liver damage.