胃癌组织中微血管密度测定与转移和预后临床分析

摘要

目的：探讨胃癌组织中的微血管密度(microvessel density， MVD)，并分析其临床意义。方法42例胃癌手术切除标本均采用免疫组织化学染色S-P法检测，检测胃癌组织CD34蛋白的表达，分析微血管密度与临床病理因素及预后的关系。结果胃癌组织中微血管密度(MVD)为40.26±12.6；癌旁边组织中微血管密度(MVD)为21.2±9.12；正常组织中微血管密度(MVD)为12.20±4.21，胃癌组织中微血管密度高于癌旁组织和正常组织，差异具有显著性(P<0.05)。胃癌微血管密度高的患者5年生存率为21.5%，低MVD组患者的生存率则为43.7%，两者相比差异具有统计学意义。结论胃癌组织中微血管密度比其它胃组织高，在一定程度上MVD具有判断胃癌切除术后转移和预后的价值。%Objective To study the clinical significance of the microvessel density (MVD). Methods The immunohistochemical method were adopted to detect CD34 expression in 42 cases of human gastric cancer patients and the correlation between the expression level and clinical pathological features was analyzed.Analysis of the microvascular density relationship with clinicopathological factors and prognosis. Results MVD in gastric cancer tissue was 40.26 ± 12.6. The beside carcinoma tissue MVD was 21.2 ± 9.12. And in the normal tissue MVD was 12.20 ± 4.21. Gastric cancer tissue microvascular density was higher than that of tissue adjacent to carcinoma and normal tissues, with significant difference. Gastric cancer patients with microvascular density of 5 a survival rate of 21.5, Surial for patients with low MVD group was 43.7, the compared the difference is statistically significant. Conclusions Gastric cancer tissue microvascular density is higher than other stomach tissue. MVD has determining value of the metastasis to some extentand prognosis after gastric cancer resection.