目的：探讨肺部感染程度对无创通气治疗慢阻肺急性加重期合并呼吸衰竭疗效的影响。方法选取我院2013年2月至2014年2月收治的80例慢阻肺急性加重期合并呼吸衰竭患者，按肺部感染程度分成研究组[肺部感染评分（VPIS)≤7分]和对照组（VPIS>7分)，每组各40例。所有患者均给予无创通气治疗，对两组的治疗效果进行分析比较。结果研究组治疗总有效率为95.0％，明显高于对照组的75.0％；研究组治疗后HR、 RR、 MAP均明显低于对照组， PaO2显著高于对照组；差异均具有统计学意义（P<0.01)。结论肺部感染程度是影响无创通气治疗慢阻肺急性加重期合并呼吸衰竭疗效的关键原因，临床上需根据不同患者肺部感染程度实施针对性治疗措施，从而提高治疗效果，改善患者生活质量。%Objective To investigate the impact of lung infection degree on the efficacy of non-invasive ventilation in treatment of acute exacerbation of COPD complicating respiratory failure. Methods 80 patients with acute exacerbation of COPD complicating respiratory failure treated in our hospital from February 2013 to February 2014 were selected. According to the degree of lung infection, 80 patients were divided into study group (CPIS≤7 points) and control group (CPIS>7 points), with 40 cases in each group. All patients were given non-invasive ventilation therapy, and the treatment effect of two groups was analyzed and compared. Results The total effective rate of study group was 95.0%, significantly higher than 75.0%of control group;the levels of HR, RR, MAP of study group were significantly lower than those of control group, the level of PaO2 of study group was significantly higher than that of control group;all the difference was statistical (P <0.01). Conclusions The degree of lung infection is the key reason affecting the efficacy of non-invasive ventilation in treatment of acute exacerbation of COPD complicating respiratory failure. Targeted treatment method should be conducted according to patients' degree of lung infection in clinic, thus improving the treatment effect and quality of life.
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