Objective To observe the effect of ulinastatin for the adjuvant treatment of children with severe sepsis. Methods 80 cases of children with severe sepsis admitted to our hospital from January 2010 to March 2012 were divided into two groups. 39 cases of control group were given routine treatment, while 41 cases of treatment group were given ulinastatin on the basis of routine treatment. The levels of IL-6, IL-10, TNF-α, CK-MB and cTnI before treatment and 7 days after treatment were detected, and the APACHEⅡscore and length of hospital stay were observed. Results Seven days after treatment, the levels of IL-6, TNF-α, CK-MB and cTnI of treatment group were significantly lower than those of control group (P<0.05), and the level of IL-10 was significantly higher than that of control group (P<0.05). The APACHEⅡscore of treatment group was significantly lower than that of control group (P<0.05), and the length of hospital stay of treatment group was significantly shorter than that of control group (P <0.05). Conclusions Ulinastatin for adjuvant treatment of children with severe sepsis can effectively improve the inflammatory markers, protect the heart function, and improve children's prognosis.%目的 观察乌司他丁治疗儿童重症脓毒症的临床疗效. 方法 收集2010年1月至2012年3月期间于我院住院治疗的80例严重脓毒症患儿分为治疗组41例和对照组39例, 对照组给予常规治疗, 治疗组在常规治疗的基础上予以乌司他丁10 000 U/kg静注, q 12 h × 7 d. 检测治疗前及治疗后第7天IL-6、 IL-10、 TNF-α、 CK-MB及cTnI水平, 比较两组的APACHEⅡ评分及住院天数. 结果 治疗后7天治疗组患儿的IL-6、 TNF-α、 CK-MB及cTnI水平较对照组明显降低 (P<0.05), 而IL-10水平较对照组高 (P<0.05). 治疗后7天, 治疗组APACHE Ⅱ评分较对照组明显降低 (P<0.05), 治疗组住院天数低于对照组(P<0.05). 结论 乌司他丁辅助治疗儿童重症脓毒症, 可有效改善各项炎性反应指标, 保护心功能, 改善患儿预后.
展开▼
