Objective To assess the prediction value of technetium-99m methoxyisobutylisonitrile(~(99)Tc~m-MIBI) for the effect of chemotherapy in small cell lung cancer (SCLC) patients. Methods Fifty-three patients with SCLC were divided into two groups according to the chest computed tomography (CT) examination, 39 patients in group A with complete or partial remission, and 14 patients in groups B with stable or progressive status. ~(99)Tc~m-MIBI was performed before chemotherapy. Following i. v. administration of 740 MBq ~(99)Tc~m-MIBI, SPECT imagings at 10 -30 minutes (early) and 2 -3 hours (delayed) were performed to obtain the uptake ratio of early phase tumorormal lung tissue (ER) and the uptake ratio of delayed phase tumorormal lung tissue (DR). The retention index (RI) was calculated as (DR-ER)/ ER × 100%. The differences of ER,DR and RI between the two groups were tested through t-test and rank sum test. Results ~(99)Tc~m-MIBI uptake was significantly higher in group A than group B: 2.33(SD:0.21) vs 2.02(SD:0.31) for the early ratio (ER) (t = -3.401, P<0.05) and 2.44(SD:0.19) vs 1.86 (SD :0.30) for the delayed ratio (DR) (t = - 6.724,P < 0.05). The median of RI in group A was signifi-cantly higher than that in group B (5.31% vs -9.26%,P <0.05). Conclusions ER,DR and RI of ~(99)Tc~m-MIBI SPECT may be helpful in predicting the response to chemotherapy in patients with SCLC.%目的 探讨~(99)Tc~m-MIBI显像预测小细胞肺癌化疗疗效的价值.方法 53例小细胞肺癌患者根据胸部CT结果分为化疗有效组(完全缓解+部分缓解)39例和无效组(病情稳定+疾病进展)14例,于化疗前行~(99)Tc~mMIBI肺显像,静脉注射~(99)Tc~m-MIBI 740 MBq后10～30 min及2～3 h分别行早期及延迟显像,分别获得早期相肿瘤与正常肺组织摄取比值(ER)和延迟相肿瘤/正常肺摄取比值(DR),计算滞留指数(RI).采用t检验及秩和检验分析化疗有效组与化疗无效组ER、DR和RI之间的差别.结果 ~(99)Tc~m-MIBI显像结果中,化疗有效组的ER、DR分别为2.33±0.21、2.44±0.19,均显著高于化疗无效组的2.02±0.31、1.86±0.30,差异有统计学意义(t=-3.401、-6.724,P均<0.05).化疗有效组的RI中位值为5.31%,高于化疗无效组的-9.26%,差异有统计学意义(Z=-3.612,P<0.05).结论 ~(99)Tc~m-MIBI显像在预测小细胞肺癌化疗疗效方面具有重要的临床价值.
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