目的：探讨合并2型糖尿病的经皮冠状动脉介入治疗术(PCI)患者术后高敏 C 反应蛋白(hsCRP)水平及其与术后心血管事件发生的相关性。方法选择38例糖尿病 PCI 患者,及38例非糖尿病 PCI 患者,收集患者一般情况,PCI 手术前后 hsCRP 情况,手术后6个月内主要不良心脏事件(MACE)发生情况,分析术后72小时 hsCRP 水平与 MACE 的相关性。结果两组一般情况比较差异无统计学意义(P >0.05)。两组患者手术后 hsCRP 水平[(15.94±3.49)μg/L,(11.67±3.28)μg/L]明显高于手术前[(7.64±3.64)μg/L,(7.59±3.38)μg/L],差异有统计学意义(P 0.05],术后糖尿病 PCI 组 hsCRP 水平明显高于非糖尿病 PCI 组,差异有统计学意义[(15.94±3.49)μg/L vs (11.67±3.28)μg/L,P 0.05).The hsCRP levels of two groups after PCI(1 5.94±3.49)μg/L,(1 1.67±3.28)μg/L were significantly higher than before PCI (7.64 ±3.64)μg/L,(7.59 ±3.38)μg/L(P <0.05).The postoperative hsCRP levels of diabetes PCI group (1 5.94±3.49)μg/L was significantly higher than that of non-diabetic PCI group (1 1.67± 3.28 )μg/L (P < 0.05 ).Within 6 months after PCI,the MACE of diabetic group 31.6% (12/38 )was significantly higher than that of non-diabetic group 13.2%(5/38)(P <0.05 ).In diabetes PCI group,MACE mainly presented with angina and non-Q-wave myocardial infarction(both 13.2%),while in non-diabetic group,MACE mainly with angina (7.9%).The blood hsCRP level of patients with type 2 diabetes mellitus was positively correlated with MACE(r =0.467,P <0.05 ).Conclusion Early inflammatory response in patients with type 2 diabetes mellitus is more severe,which can promote the emergence of restenosis and MACE.
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