维生素D水平与成人支气管哮喘关系的Meta分析

摘要

Objective To investigate the relationship between serum vitamin D level and bronchial asthma in adults.Methods We searched the CoChrane Library,PubMed,EMbase,Web of science,OVID,Springerlink,Wiley online library,ScienceDirect,EBSCOhost,CNKI,VIP,Wanfang data databases from inception to May 1st 2017 to collect studies about the association between vitamin D and adult asthma.Two reviewers independently screened literature according to inclusion and exclusion standard,extracted data and assessed the quality of included studies. Then,meta-analysis was performed using RevMan 5.3 software.Results Nine case-control studies involving 827 asthma patients and 287 controls were finally included.The meta-analysis showed that 25(OH)D in adult asthma group was lower than that in control group (MD = -15.90,95％ CI = -18.55--13.25,P < 0.01 ).Adult asthma presented more vitamin D deficiency than the controls(RR = 2.03,95％ CI = 1.57-2.63,I 2 = 0％,P = 0.79 ).In asthma patients,FEV1 ％ in vitamin D deficiencies was lower than that of the normal (MD = -9.78,95％ CI =-12.21--7.36,P <0.01).Conclusion Vitamin D level is associated with asthma in adults.Vitamin D deficiency is common in patients with asthma and associated with lung function.The lack of vitamin D may be one of the potential risk factors for asthma.%目的 系统评价血清中维生素D水平与成人支气管哮喘的关系.方法 计算机检索CoChrane Library,PubMed,EMbase,Web of science,OVID,Springerlink,Wiley online library,ScienceDirect,EBSCOhost,中国知网,维普数据库,万方数据库,检索建库至2017年5月1日发表的关于维生素D与成人哮喘相关性的研究.由2位研究者独立按照纳入与排除标准进行文献选择、资料提取和质量评价后,采用RevMan5.3软件进行Meta分析.结果 共纳入9个研究,均为病例对照研究,包括827例患者和287例对照.Meta分析结果显示:成人哮喘组25(OH)D水平低于对照组(MD=-15.90,95％CI=-18.55～-13.25,P<0.01);成人哮喘患者比对照组更易发生维生素D不足(RR=2.03,95％CI=1.57～2.63,I 2=0％,P=0.79);成人哮喘患者中维生素D不足者FEV1％水平低于维生素D正常者(MD=-9.78,95％CI=-12.21～-7.36,P<0.01).结论 维生素D水平与成人哮喘有关,哮喘患者普遍存在维生素D不足,维生素D不足与肺功能相关,维生素D不足可能是哮喘的潜在危险因素之一.