目的：检测妊娠高血压疾病患者血清胎球蛋白-A（FA）和超敏C反应蛋白（hsCRP）的水平，探讨FA与妊娠高血压疾病发病的关系。方法选择妊娠高血压疾病组93例（子痫前期轻度组30例、子痫前期重度组31例、子痫期组32例），正常妊娠组30例，测定其血清中FA和hsCRP浓度，同时测定胰岛素抵抗指数和血脂，分析血清FA水平与hsCRP和HOMA-IR等的相关性。结果子痫前期轻度组、子痫前期重度组和子痫期组的血清FA、hsCRP水平均明显高于正常妊娠组，差异均有统计学意义（q分别=2.81、2.74、2.55；2.11、2.23、2.52，P均＜0.05），子痫期组、子痫前期重度组的FA和hsCRP均明显高于子痫前期轻度组，差异均有统计学意义（q分别=3.11、2.89、2.95、3.02， P均＜0.05）；子痫期组FA和hsCRP均明显高于子痫前期重度组，差异均有统计学意义（q分别=3.34、3.09， P均＜0.05）；妊娠高血压疾病患者血清FA水平与血清hsCRP和HOMA-IR呈正相关（r分别=0.39、0.27， P均＜0.05）。结论血清FA水平在妊娠高血压疾病患者中明显增高，与病情严重程度有关，同时FA与hsCRP水平和HOMA-IR呈正相关，提示血清FA水平可作为临床观察妊娠高血压疾病的重要指标。%Objective To detect the level of serum fetuin-A and hsCRP in patients with gestational hypertension and explore the relationship between FA and the incidence of gestational hypertension. Methods Ninety-three patients with gestational hypertension including 30 cases of mild preeclampsia, 31 cases of severe preeclampsia and 32 cases of eclamp-sia were selected as well as 30 cases of normal pregnancy. Serum levels of FA, hsCRP, HOMA-IR and blood lipid were measured and the relationships among them were analyzed. Results The FA level of mild preeclampsia group, severe preeclampsia group and eclampsia group were significantly higher than those of normal pregnancy (q=2.81,2.74,2.55,P<0.05) as well as hsCRP level (q=2.11,2.23,2.52,P<0.05). The FA and hsCRP levels of eclampsia group and severe preeclampsia group were significantly higher than those of mild preeclampsia group (q=3.11,2.89,2.95,3.02,P<0.05). The FA and hsCRP levels of severe preeclampsia group were significantly higher than those of eclampsia group (q=3.34,3.09, P<0.05). The FA were positively related with hsCRP and HOMA-IR (r=0.39,0.27,P<0.05). Conclusions Serum FA levels in gestational hypertension is significantly increased with the disease severity. The FA levels were positively related with hsCRP and HOMA-IR which suggested that serum FA level can be used as clinical observation indicator of gestational hypertension.
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