Objective To explore the guiding significance of two-dimensional speckle-tracking imaging (2D-STI) for evaluating the left ventriculartorsion in patients with atrial septal defect before and after the transcatheter closure surgery. Methods A total of 30 patients with atrial septal defect were selected as the obervation group , and another 30 healthy volunteers were enrolled as the control group. The rotation of each segments of basal and apical short-axises in left ventricular, peak systolic time and overall reverse angle in systole of left ventricular at pre-operation, the 3 and 6 months after the operation between two groups were measured. The conventional parameters including left ventricular evening diastolic volume (LVEF), left ventricular evening systolic volume (LVEF), left ventricular stroke volume (LVEF) and left ventricular ejection fraction (LVEF) were detected by double plane simpson method. Results At pre-operation, the LVEDV,LVESV,LVSV in the observation group were significantly lower than those in the control group(t=7.56,5.74,3.82, P<0.05),and increased at 3 months after the operation, but lower than the control group(t=11.82,10.47,8.75,15.25, 11.34,9.57,P<0.05), those significantly increased at 6 months after the operation,but lower than the control group (t=13.84,11.25,9.73,17.57,14.82,10.69,P<0.05).The LVEF did not change significantly at each time in two groups (F=0.84,P>0.05). At pre-operation, the left ventricular basal short-axis except the anterior wall in the observation group, other segmental rotation angle were significantly lower than those in the control group (t=8.82,9.47, 13.43,10.15,13.52,P<0.05),except the anterior wall ,other segmental rotation angle increased at 3 and 6 months after the operation(t=9.67,8.75,10.31,9.89,11.02,14.28,12.46, 14.51,12.39,17.54,P<0.05). At pre-operation, the torsion angle of the whole left ventricular in the observation group was significantly lower than the control group (t=8.84,P<0.05),and increased at 3 and 6 months after the operation, but lower than the control group (t=9.24,6.47,7.75,3.68,P<0.05). Conclusion 2D-STI could evaluate quantitatively left ventricular torsion in patients with atrial septal defects before and after the transcatheter closure , by the method of measuring left ventricular basal short-axis department , apical short-axis department of rotation angle and left ventricular overall reverse angle, further evaluate the left ventricular function of contraction earlier.%目的：应用二维斑点追踪显像技术（2D-STI）评价房间隔缺损患者封堵术前后左室扭转运动的指导意义。方法选取30例单纯房间隔缺损患者作为病例组，另选取30例健康志愿者作为对照组，分别测量病例组的术前、术后3个月、术后6个月和对照组的左室短轴基底水平、左室短轴心尖水平各节段的收缩期旋转角度及达峰时间、测量收缩期左室整体扭转角度；绘出左室短轴基底水平及左室短轴心尖水平收缩期旋转角度-时间曲线；双平面Simpson法测量各组的常规参数：舒张末期容积（LVEDV）、收缩末期容积（LVESV）、每搏输出量（LVSV）、左室射血分数（LVEF）。结果病例组患者术前的LVEDV、LVESV、LVSV明显低于对照组（t分别=7.56、5.74、3.82，P均＜0.05）。术后3个月升高，但低于对照组（t分别=11.82、10.47、8.75、15.25、11.34、9.57，P均＜0.05），术后6个月明显升高但仍低于对照组（t分别=13.84、11.25、9.73、17.57、14.82、10.69，P均＜0.05）。两组各时间点的左室射血分数变化不明显（F=0.84，P＞0.05）。病例组患者术前左室短轴基底水平除前壁外，余各节段旋转角度峰值均低于对照组（t分别=8.82、9.47、13.43、10.15、13.52，P均＜0.05）；术后3个月和6个月除了前壁外，余各节段较术前明显升高（t分别=9.67、8.75、10.31、9.89、11.02、14.28、12.46、14.51、12.39、17.54，P均＜0.05）。病例组患者术前左室整体扭转角度明显低于对照组（t=8.84，P＜0.05）；与术前比较，术后3个月和6个月升高，但低于对照组（t分别=9.24、6.47，7.75、5.68，P均＜0.05）。结论2D-STI可以通过测量经皮房间隔缺损封堵术前后左室基底部、心尖部各节段的旋转和左室整体扭转角度来早期定量评估房间隔缺损患者封堵术前后的左室扭转运动情况，进而早期评价左心收缩功能。
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