不同时间窗及疗程的高压氧治疗对急性脑梗死的影响

摘要

Objective To evaluate the efficacy and safety of different time-windows and courses of hyperbaric oxygenation in patients with acute ischemic stroke. Methods 140 patients were divided into 7 groups according to the starting time-windows and courses of hyperbaric oxygenation. Hyperbaric oxygenation were administered at less than 12 h,12 h to 7 d,more than 7 days after infarction with courses of 20 or 40 d. National institues of health stroke scale(NIHSS) , activity of daily life(ADL) and electroencephalogram (EEG) were examined pre- and post-treatment. Results With the same course of hyperbaric oxygenation, the earlier hyperbaric oxygenation,the better the NIHSS, ADL and EEG evaluation got (P<0. 05) ;With the same time-window of hyperbaric oxygenation, the longer the course of hyperbaric oxygenation, the better the NIHSS, ADL and EEG evaluation got (P<0. 05). Conclusion The efficacy and safety of hyperbaric oxygenation are reliable in acute ischemic stroke,and the best therapeutic time-window is less than 12 h after stroke attacked. But there still exist significant improvement in 7 d post-stroke,and the longer the course took,the better the result improved.%目的 探讨不同时间窗及疗程的高压氧治疗对急性脑梗死疗效的影响.方法 140例急性脑梗死患者按从发病到高压氧治疗的时间窗及疗程分为7组,对各组患者在高压氧治疗前、后分别进行神经功能缺损程度、日常生活活动能力(ADL)评分及脑电图检查,并进行各组之间的比较.结果 在进行同样疗程的高压氧治疗中,越早进行高压氧治疗,患者美国国立卫生研究院卒中量表(NIHSS)、ADL评分及脑电图结果越好,差异有统计学意义(P<0.05);相同时间开始高压氧治疗,疗程越长,患者的NIHSS、ADL评分及脑电图结果越好,差异有统计学意义(P<0.05).结论 高压氧治疗急性脑梗死疗效可靠,在脑梗死后12 h以内开始高压氧治疗效果最好,7 d后开始行高压氧治疗仍有临床疗效,并且疗程越长疗效越佳.