食管癌患者血清骨桥蛋白水平检测的临床意义

摘要

目的 通过对食管癌患者血清骨桥蛋白(OPN)水平的检测,探讨OPN在食管癌辅助诊断、转移和预后监测中的作用.方法 采用酶联免疫吸附试验检测食管癌患者和健康志愿者血清OPN.结果 食管癌患者血清OPN水平明显高于健康志愿者(P<0.05),食管癌患者有远端转移者血清OPN水平显著高于无转移者(P<0.05),食管癌患者术后血清OPN水平显著下降(P<0.05).结论 血清OPN水平是一个较好的评价食管癌发生、发展的指标,血清OPN检测有助于临床对食管癌治疗效果的评判.%Objective To study the clinic significance of serum OPN levels in esophageal carcjnorna patients. Methods Serum OPN levels were performed by EL∧SA. Results The serum OPN levels in esophageal carcinoma patients were significantly higher than controls(P＜0.05). The serum OPN levels in esophageal carcinorna patients with metastasis were significantly higher than patients without metastasis(P＜0.05). Furthermore,the serum OPN levels in esophageal carcinoma patients were decreased significandy after operation therapy. Conclusion Detection of serum OPN might be helpful for prognosis for esophageal earcinorna patients.