表皮生长因子对脑损伤患者骨折愈合的影响

摘要

目的 探讨表皮生长因子(EGF)对脑损伤后患者骨折愈合的影响.方法 随机选择本院住院治疗的脑损伤合并骨折患者30例作为研究对象(研究组).选取30例单纯脑损伤患者作为对照1组,30例单纯骨折患者作为对照2组.所有患者均于入院后24 h内,入院后4、7、14 d分别抽取清晨空腹外周静脉血检测血液中的EGF水平.结果 研究组EGF入院24 h内的水平即高于对照1组及对照2组,7 d内的EGF水平均持续上升,并一直高于对照1、2组(P＜0.05);对照1、2组入院后至14 d的EGF水平均呈现持续升高的趋势,并且对照1组的EGF水平高于对照2组,但差异无统计学意义(P>0.05).通过重复测量方差分析,各组间不同时间点以及不同组EGF水平随时间变化的趋势差异均有统计学意义(P＜0.05).结论 脑损伤合并骨折的患者血清中EGF水平明显增加,血清中EGF可能是参与骨折愈合过程的主要因素.%Objective To explore the effect of epidermal growth factor(EGF) on fracture healing of the brain trauma patients. Methods A total of 30 brain trauma patients with fracture were collected as observation group. 30 patients only with brain trauma were selected as control group 1. 30 patients with only fracture were selected as control group 2. EGF in the observation and control groups were detected within 24 h,on 4,7,14 d after hospital ization. Results The level of EGF within 24 h after hospitalization in the observation group was significantly higher than that in the control group 1 and 2. EGF within 7 d showed continuing increasing and was significantly higher than that in the two control groups(P<0. 05). On 14 d,EGF in the control 2 groups also showed continuing increasing trend,and the EGF level in the control group 1 was higher than that in the control group 2 without statistical difference between them(P>0. 05). By the variance analysis of repeated measures,the trend differences of the EGF levels with time change in different groups and timepoints showed statistical significance(P<0. 05). Conclusion The serum EGF level is significantly increased in brain trauma patients with fracture, and serum EGF might be the important factor participating in the healing process of fracture.