105例鼻咽癌组织VEGF和存活蛋白表达的临床意义

摘要

目的 联合检测鼻咽癌组织中血管内皮生长因子(VEGF)和存活蛋白表达的相关性及与预后的关系.方法 应用免疫组织化学法检测105例患者鼻咽癌组织放疗前VEGF和存活蛋白的表达情况,随访5～7年,所有资料经SPSS13.0软件统计包处理,进行χ2检验、spearman相关分析、生存分析.结果 (1)105例鼻咽癌组织中VEGF和存活蛋白阳性表达率分别为76%和58%,显著高于正常鼻咽组织中阳性表达.(2)VEGF和存活蛋白同时表达与鼻咽癌患者的年龄、T分期、TNM分期、颅底侵犯有明显相关性(P<0.05);VEGF和存活蛋白的表达呈明显正相关性(P<0.05).(3)VEGF和存活蛋白同时阴性表达的患者较二者同时高表达的患者有较高的5年生存率(P<0.05).结论 VEGF和存活蛋白在鼻咽癌组织中高表达,二者之间有密切相关性,且均与患者的生存率呈负相关.%Objective Combined detection of the expression of VEGF and survivin protein of nasopharyngeal carcinoma were done to study the correlation about two proteins and the prognosis in nasopharyngeal carcinoma. Methods Immunohistochemistry was used to determinate the expression of VKGF and survivin protein in tissue in 105 nasopharyngeal carcinoma patients. Followed up from 5 to 7 years,the rate of following up was by 95%. The methods that were used to analyze the data were chi-squre test, spearman rank correlation,survival analysis. The analysis was done by SPSS13. 0 software. Results (1) The positive expression of VKGF and survivin protein in nasopharyngeal carcinoma were 76% , 58% , respectively, which had statistical significance between carcinoma group and normal tissue group. (2) VEGF and survivin expression were significant correlation with the age,T stage, TNM stage and skull base invasion in patients with nasopharyngeal carcinoma. There was a significant positive correlation between the expression of VEGF and survivin (P<0. 05). (3)The negative expression of VEGF and survivin proteins at the same time had better 5 years survival rate than high positive expression of them(P<0. 05). Conclusion There is an abnormal high expression and significant positive correlation of VEGF and srnvivin in nasopharyngeal carcinoma,high expression of two proteins at the same time has negative correlation with the survival rate in patients.