黄酮甙对大鼠胃泌素及胃运动的影响

摘要

目的 研究黄酮甙对胃泌素及胃运动的影响.方法 实验组(A组)从枳实中提取黄酮甙对大鼠灌胃,B组用红霉素对大鼠灌胃,C组用生理盐水对大鼠灌胃.检测各组大鼠血浆中胃泌素含量,用生理记录仪记录黄酮甙对胃排空和胃运动的影响.结果 A、B组与C组比较,大鼠血浆中胃泌素含量均明显增高(P＜0.05);A组胃泌素含量明显高于B组(P＜0.05).A、B组胃肌电慢波频率与C组比较,差异有统计学意义(P＜0.01);A组与B组比较,差异也有统计学意义(P＜0.05).结论 黄酮甙通过促进胃泌素的分泌提高胃的收缩力,增强胃排空来调节胃运动.%Objective To study the influences of gastrin(the active ingredient of frutus) on stomach movement function and se-cretion by flavonoids glucoside. Methods The rats of group A were irrigated stomach with flavonoids glucoside extracted from frutus, the rats of group B with erythromycin,the rats of group C with saline water. Extracted serum from all these rats,and detected gastrin,studied the influences of stomach on movement and emptying function by physiological recorder. Results The levels of gas-trin in group A and B were significantly higher than group C;The level of gastrin in group A was significantly higher than group B (P<0. 05). The changes of stomach muscle electricity were significiant differences in group A and B comparing with group C(P< 0. 01) ; There was a remarkable difference in stomach muscle electricity between group A and B(P<0. 05). Conclusion Flavonoids glucoside of frutus can improve the stomach contraction and enhance gastric emptying by enhancing the secretion of gastrin.