比较唑来膦酸与利塞膦酸在激素诱导的骨质疏松中的疗效

摘要

目的 比较唑来膦酸与利塞膦酸在激素诱导的骨质疏松中的疗效.方法 选取本院2007年1月至2010年1月糖皮质激素诱导的骨质疏松患者120例,随机双盲试验,分为唑来膦酸组60例,利塞膦酸组60例,疗程均为连续治疗12个月.比较两组患者的骨密度及血清β-CTx及骨形成标志物P1NP浓度等指标.结果 唑来膦酸组患者治疗后血清β-CTx浓度远低于利塞膦酸组患者血清浓度(P＜0.05).结论 唑来膦酸静脉滴注能够显著增加腰椎及股骨颈骨密度基值,降低β-CTx及P1NP血清浓度,治疗效果远优胜于利塞膦酸.%Objective To compare the efficacies of zoledronic acid and risedronate in treating glucocorticoid induced osteoporo sis. Methods 120 patients with glucocorticoid induced osteoporosis in this hospital from January 2007 to January 2010 were select ed and divided into the zoledronic acid group and the risedronate group by using the randomized,double blind test,with 60 cases in each group. The treatment course was continuous 12 months in two groups. The bone mineral density and serum β CTx and P1NP concentrations were detected and compared between the two groups. Results Serum β CTx concentration in the zoledronic acid group was significantly lower than that in the risedronate group(P-<0. 05). Conclusion Intravenous infusion of zoledronic acid can significantly increase the basic value of the bone mineral density in lumbar vertebra and femoral neck, decrease serum β CTx andrnP1NP concentrations,its curative effects are obviously superior to risedronate.