趋化因子10在慢性非萎缩性胃炎、胃癌癌前病变及胃癌中的表达及意义

摘要

Objective To investigate the expressions of CXC chemokine 10(CXCL10) in chronic non-atrophy gastritis(CNAG) , precancerous lesions(PL)and gastric cancer(GC) ,primitively understanding of CXCL10 expression levels in three gastric types ,ex-ploring their clinical significances .Methods The expressions of CXCL10 in 20 cases of CNAG ,60 cases of PL ,60 cases of GC tis-sues were examined with immunohistochemistry method ,the expression level of CXCL10 was analyzed by computer-assisted image analysis system ,and then analyzed statistically .Results CXCL10 expression were positive in parts of CNAG ,PL and GC the posi-tive rates were 10 .00% ,26 .67% ,71 .67% respectively) .Expression levels of CXCL10 in the GC tissue specimens were significant-ly higher than in CNAG and PL(P<0 .01) .Expression levels of CXCL10 in the PL and CNAG tissue specimens have no significant difference(P>0 .05) .Expression levels of CXCL10 in CAG with IM ,CAG with Dys had no significant difference(P>0 .05) ,and in CAG with Severe Dys and Light-Moderate Dys had no significant difference(P>0 .05) .The expression levels of CXCL10 were rele-vant to the differentiation degree of GC (P>0 .05) .Conclusion The expression levels of CXCL10 were gradually rose from CNAG , PL to GC ,and had significant correlation with each other in CNAG ,PL and GC ,indicating that CXCL10 have a key role in the pro-duce and development of GC .%目的：检测趋化因子10（CXCL10）在慢性非萎缩性胃炎（CNAG）、癌前病变（PL）和胃癌（GC）中的表达情况，探讨CXCL10蛋白与GC临床特征及胃黏膜癌变机制的关系。方法应用免疫组织化学SP法检测CXCL10蛋白在20例CNAG、60例PL及60例GC患者胃黏膜中的表达。并应用计算机辅助图像分析仪对表达结果进行图像分析，然后进行统计学分析。结果CXCL10蛋白在CNAG、PL和GC中的表达阳性率分别为10．00％、26．67％、71．67％；CXCL10蛋白阳性表达率在GC组显著高于CNAG及PL组（均为 P＜0．01）；CXCL10蛋白在PL、CNAG两种病理组织中阳性表达率差异无统计学意义（P＞0．05）；在PL组中，CXCL10的阳性表达率在肠化及不典型增生组中差异无统计学意义（P＞0．05），在不同程度增生的不典型增生组中差异亦无统计学意义（P＞0．05）。在GC组中，中低分化GC组CXCL10蛋白阳性表达率显著高于高分化组。结论随着GC演进， CXCL10蛋白阳性表达率逐渐升高，可见CXCL10蛋白在GC演进过程中异常扩增提示其可能对GC的形成起一定的调控作用。