Objective To research the expression and clinical significance of SALL 4 gene in cervical cancer .Methods The ex-pression of SALL4 in 56 samples of cervical cancer and 35 samples of normal cervical tissues was detected by immunohistochemistry and RT-PCR ,and its relationship with the clinicopathological characteristics of cervical cancer was analyzed .Results The expres-sion of SALL4 mRNA was 2 .56 ± 0 .22 in cervical cancer tissues ,which was significantly higher than 0 .38 ± 0 .03 in the normal cer-vical tissues .the difference between them had statistical significance(t=58 .1 ,P<0 .01);the positive expression rate of SALL4 pro-tein was 80 .4% (45/56) in cervical cancer ,which was significantly higher than 11 .4% (4/35) in the normal cervical tissues (χ2 =41 .177 ,P<0 .01) .The positive expression of SALL4 in the cervical cancer tissues was correlated with the differentiation status of tumor ,which in the middle and high differentiation groups was lower than that in the low differentiation group (χ2 =4 .226 ,P=0 .039) ,but had no correlation with age ,International Federation of Gynecology and Obstetrics (FIGO) stage ,tumor size ,pathologi-cal type and lymph node metastasis(P>0 .05) .Conclusion SALL4 is highly expressed in the cervical cancer tissues and correlated with the tumor differentiation ,which might play an important role in the occurrence and development of cervical cancer .%目的：研究SALL4基因在宫颈癌组织中的表达情况及其临床意义。方法利用RT-PCR和免疫组化方法检测56例宫颈癌组织和35例正常宫颈组织中SALL4的表达，并分析SALL4在宫颈癌中的表达与临床病理特征的关系。结果宫颈癌组织中SALL4 mRNA表达水平（2．56±0．22）高于正常宫颈组织（0．38±0．03），二者比较差异有统计学意义（t＝58．1，P＜0．01）；SALL4蛋白在宫颈癌组织中阳性表达率（80．4％，45/56）高于宫颈正常组织（11．4％，4/35），二者比较差异有统计学意义（χ2＝41．177，P＜0．01）。宫颈癌组织中SALL4的阳性表达与肿瘤分化状态相关，中、高分化组低于低分化组（χ2＝4．226，P＝0．039），与年龄、国际妇产科学联盟（FIGO ）分期、肿瘤大小、病理类型、淋巴结是否转移无关（χ2＝0．004、3．403、1．223、0．827、0．011，P＞0．05）。结论 SALL4在宫颈癌组织中高表达，与宫颈癌的分化相关，SALL4的表达可能对宫颈癌的发生发展有重要作用。
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