即刻行颞浅动脉逆行置管化疗技术对口腔鳞癌患者术后化疗的疗效观察

摘要

目的：对口腔鳞癌患者采用不同化疗给药途径并观察奈达铂（nedaplatin，NDP）和5‐氟尿嘧啶（5‐fluorouracil，5‐Fu）的疗效和不良反应。方法将64例口腔鳞癌患者分为术后普通静脉化疗组（IV组，32例）和术中即刻行颞浅动脉逆行置管化疗组（IA组，32例），两组化疗方案都为DNP和5‐Fu，其中IA组剂量为IV组的1／3，观察疗效和不良反应。结果IA组疗效优于IV组（P＜0．05），同时IA组在骨髓抑制、胃肠道反应及口腔黏膜炎等化疗后并发症较IV组轻，差异有统计学意义（P＜0．05）。结论术中IA疗效明显，不良反应轻且安全，适合临床推广。%Objective Treat patients with oral squamous cell carcinomas with different chemotherapy administration route ,and observe the effects and adverse reaction of Nedaplatin (NDP) and 5‐Fluorouracil (5‐Fu) .Methods Sixty four patients with oral squamous cell carcinomas were randomly divided into two groups which included intravenous chemotherapy group (IV)(with 32 ca‐ses) and intra‐artery infusion via the superficial temporal artery group (IA)(with 32 cases) .Each group was treated with NDP and 5‐Fu .The dose of the IA group was one third of that of the IV group .Efficacy and side effect had been observed .Results Efficacy of the IA group was better than that of the IV group (P<0 .05) .Complications including bone marrow suppression ,gastrointestinal reactions and oral mucositis of the IA group was lighter than that of the IV group ,which was significantly different (P<0 .05) . Conclusion The retrograde intra‐arterial chemotherapy via the superficial temporal artery during the surgery is safe ,effective and useful ,and it is worth of further clinical application .