强化他汀治疗对不稳定心绞痛患者自身免疫的影响

摘要

Objective To explore the impact of high‐load atorvastatin on T cell subsets in patients with unstable angina (UA) after percutaneous coronary intervention (PCI) .Methods One hundred and eighty patients with UA were randomly divided into high‐load atorvastatin group ,ordinary‐load atorvastatin group and routine group ,60 cases in each group .The ratios of CD4+ T cell , CD8+ T cell and the frequencies of CD4+ CD25+ Treg were detected in 3 groups 1 day before PCI and 1 week ,1 month and 6 months after PCI by flow cytometry analysis .Results Different doses of atorvastatin reduced the ratio of CD4+ T cells and in‐creased the ratio of CD8+ T cells and also the frequencies of CD4+ CD25+ Treg after PCI for 1 week ,1 month and 6 months .The longer the time to take atorvastatin ,the more obvious the effect was(P<0 .05) .The ratios of CD4+ ,CD8+ T cells and the frequen‐cies of CD4+CD25+ Treg after PCI for 1 month and 6 months in high‐load atorvastatin showed significant difference compared with those in ordinary‐load atorvastatin group and routine group(P<0 .05) .Conclusion Atorvastatin could regulate the balance of T cell subsets in patients with UA ,and thus it may reduce the UA onset and the treatment effect of high‐load atorvastatin is more sig‐nificant .%目的：探讨强化他汀治疗对行经皮冠状动脉介入术（PCI）术后不稳定心绞痛（UA）患者外周血T细胞亚群的影响。方法选择2012年9月至2013年4月在唐山市工人医院住院并行PCI术的UA患者180例分为高负荷量他汀治疗组、常规负荷量他汀治疗组、常规治疗组，每组60例。采用流式细胞分析法检测各组患者术前1d和术后1周、1个月、6个月外周血CD4＋，CD8＋细胞占T淋巴细胞比例，CD4＋CD25＋Treg细胞占CD4＋T细胞比例。结果不同剂量的阿托伐他汀钙在术后1周、1个月、6个月均可降低CD4＋T细胞比例，升高CD8＋T细胞比例，同时升高CD4＋CD25＋Treg细胞占CD4＋T细胞比例且服用时间越长效果越明显（P＜0．05）；高负荷量他汀治疗组在术后1个月、6个月外周血CD4＋，CD8＋细胞占T淋巴细胞比例和CD4＋CD25＋Treg细胞占CD4＋T细胞比例与同时间点常规负荷量他汀治疗组和常规治疗组相比差异亦有统计学意义（P＜0．05）。结论阿托伐他汀钙通过调节UA患者外周血T细胞亚群的平衡状态而降低UA的发病且强化他汀治疗后临床疗效更显著。